Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 May 4;9:87. doi: 10.1186/1742-2094-9-87

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright ©2012 Pintado et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:// http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Proteasome inhibition after intrahippocampal injection of LPS induced the formation of aggresome-like structures in hippocampal neurons. (A) Upper: immunofluorescence analysis of the cellular distribution of ubiquitinated proteins in hippocampal slices from rats treated with saline, saline + LPS, saline + LT and LPS + LT. Images correspond to animals sacrificed 48 hours after the last injection. Lower: higher magnification corresponding to neurons from the stratum pyramidale taken from images showed above. Nuclei were counterstained with DAPI. Note the presence of large aggresome-like structures (arrowheads) only in the LPS + LT-injected rats. Bar scale: 75 μm for upper images and 10 μm for lower images. (B) Similar as in A but images correspond to aged rat hippocampus injected with LT alone. DAPI: 4′-6-diamidino-2-phenylindole; LPS: lipopolysaccharide; LT: lactacystin; sp: stratum pyramidale.