Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Detecting assembly defects using CHA circuits. In the perfectly formed mAP structure (a), the toehold (shown in red) is only partially exposed, whereas defects near the hybridization junction may fully expose the toehold (b). The hybridization defects can be mimicked by introducing point mutations on the mOS strand, which stimulate the activity of mAP to different extent (c). T18A* (Sample #7) denotes 1:5-diluted T18A variant of mOS.
