Table 3. Regions showing ALFF differences of the patients after TIPS in paired comparison.

Time	Brain regions	BA	MNI coordinates (mm)	ΔVol (mm3)	Peak t value
			(x, y, z)
Median 8-day follow-up	Left middle/posterior cingulate cortex	31/23	−3,−39,39	486	−2.98
	Right SMA	6	3,18,51	459	−3.08
	Left DLPFC	9/45	−54,9,21	459	−3.12
	Left MPFC	10	−3,63,3	594	−3.01
	Left ACC	10/32	−12,30,−12	594	+4.33
Median 3-month follow-up	Left DLPFC	9/6	−51,0,27	648	−3.24
	Left ACC	25	−9,12,−6	540	−3,13
	Left MPFC	10	−6,66,0	756	−3.45
	Left PCC	23	−6,−45,21	324	−3.28*

Positive sign in the peak t-score represents increase, and negative sign represents decrease. All P<0.05, corrected for multiple comparisons using AlphaSim program. ^*The region in the posterior cingulate cortex survived the height but not the extent threshold. ΔVol: volume difference; ALFF  =  amplitude of low frequency fluctuation; TIPS  =  Transjugular intrahepatic portosystemic shunt; BA  =  Brodmann's area; SMA  =  supplementary motor area; DLPFC  =  dorsal lateral prefrontal cortex; MPFC  =  medial prefrontal cortex; ACC  =  anterior cingulate cortex; PCC  =  posterior cingulate cortex.