Table 1. Genes present in the top Ingenuity Pathway Analysis pathways in the active TB 664-transcript signature.

Interferon Signaling		Altered T & B cell Signaling In Rheumatoid arthritis		Role of Pattern Recognition Receptors in Recognition of Viruses & Bacteria		TREM1 Signaling		Role of Macrophages, Fibroblasts, Endothelial cells in Rheumatoid Arthritis		Systemic Lupus Erythematous Signaling
Gene	FC	Gene	FC	Gene	FC	Gene	FC	Gene	FC	Gene	FC
IFI35	2.32	CD40LG	−3.09	C5	2.45	CASP1	2.11	C5	2.45	C5	2.45
IFIT3	5.81	CD79A	−5.09	C1QB	24.63	CASP5	8.58	CREB5	3.70	CD3E	−2.20
IFITM1	2.39	CD79B	−2.15	C1QC	4.66	IL1B	2.29	F2RL1	2.27	CD40LG	−3.09
IRF1	2.26	FAS	2.43	CASP1	2.11	ITGAX	4.97	FCGR1A	10.37	CD79A	−5.09
JAK2	2.38	FCER1G	2.05	IFIH1	2.39	JAK2	2.38	IL15	5.53	CD79B	−2.15
SOCS1	3.33	IL15	5.53	IL1B	2.29	NOD2	2.50	IL18R1	2.41	FCER1G	2.05
STAT1	3.40	IL1B	2.29	IRF7	2.25	PLCG1	−2.02	IL18RAP	2.32	FCGR1A	10.37
TAP1	2.42	IL1RN	2.06	NLRC4	3.17	TLR2	3.12	IL1B	2.29	FCGR1B	12.33
		SLAMF1	−2.84	NOD2	2.50	TLR5	3.07	IL1RN	2.06	FCGR1C	9.66
		TLR2	3.12	TLR2	3.12			IRAK3	2.05	FCGR2C	5.03
		TLR5	3.07	TLR5	3.07			JAK2	2.38	FCGR3B	2.13
		TNFSF13B	2.36					MAPK14	5.04	IL1B	2.29
								NFAT5	2.56	IL1RN	2.06
								OSM	2.76	LCK	−2.22
								PDGFA	2.16	NFAT5	2.56
								PLCG1	−2.02	PLCG1	−2.02
								SOCS1	3.33	TNFSF13B	2.36
								SOCS3	4.06
								TLR2	3.12
								TLR5	3.07
								TNFSF13B	2.36
								TRAF5	−2.12

FC  =  fold change. TREM1 =  triggering receptor expressed on myeloid cells.