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. 2012 Oct 2;7(10):e46666. doi: 10.1371/journal.pone.0046666

Figure 3. Heat hyperalgesia induced by intraplantar injection of CFA was inhibited by intrathecal administration of roscovitine.

Figure 3

PWL to thermal stimuli significantly decreased after intraplantar injection of CFA; **p<0.01, n = 6, per group (A). PWL to thermal stimuli significantly increased following pre-intrathecal injection of roscovitine (Ros) 30 min before intraplantar injection of CFA compared to the PWL of the control group pretreated with DMSO, **p<0.01 (B). Intrathecal adminstration of roscovitine had no effect on the threshold of heat hyperalgesia of the contralateral paws of control groups. p>0.05, cont (contralateral) to hind paw injected with saline or CFA; Ipsi, ipsilateral to hind paw injected with CFA. Data are expressed as the mean ± SEM (n = 6/group).