Table 2.
Characteristics and Outcomes of Patients Who Underwent Surgery for Papillary Thyroid Cancer, by Age Group
| Characteristic | Age 15–39 years (N=455) | Age ≥40 years (N=556) | P value (15–39 vs 40+) |
|---|---|---|---|
|
| |||
| Gender | |||
| Female | 378 (83.1%) | 386 (69.4%) | < 0.001 |
| Male | 77 (16.9%) | 170 (30.6%) | |
| TNM Stage | |||
| I | 298 (94%) | 234 (56%) | < 0.001 |
| II | 19 (6%) | 69 (16.5%) | |
| III | 91 (21.8%) | ||
| IV | 24 (5.7%) | ||
| Mean tumor size (± STD) in cm | 2.19 (1.53) | 2.77 (2.42) | 0.075 |
| Rate of lymph node metastasis (in %) | 31 | 22 | 0.008 |
| Rate of distant metastasis (in %) | 4 | 6.5 | 0.08 |
| Recurrence | |||
| None or disease-free | 293 (64.5%) | 317 (57.1%) | 0.017 |
| Recurrence | 32 (7.1%) | 34 (6.1%) | 0.523 |
| Death | 11 (2.4%) | 121 (21.8%) | <0.001 |
| Unknown | 118 (26%) | 83 (15.0%) | <0.001 |
| Surgery | |||
| Lobectomy | 31 (6.8%) | 93 (16.7%) | <0.001 |
| Subtotal or near total thyroidectomy | 75 (16.5%) | 91 (16.4%) | 0.966 |
| Total thyroidectomy | 338 (74.3%) | 352 (63.3%) | <0.001 |
| Disease-free Survival | |||
| Mean (±STD) in weeks | 597.68 (15.2) | 531.11 (15.0) | 0.0126 |
| Median (95%CI) | 568 (493.1–623.1) | 497.57 (417.1–525.7) | |
| Overall Survival | |||
| Mean (±STD) in weeks | 615.30 (14.1) | 532.08 (13.1) | 0.0013 |
| Median (95%CI) | 560.29 (525.3–641.01 | 476.29 (436.3–522.4) | |