Table 5.

Gene set enrichment analysis

Gene set	Description (from MSigDB)	Direction of regulation in AYA	Normalized enrichment score	Nominal p-value
NITROGEN_METABOLISM	Nitrogen metabolism reference pathway	Down	−1.73	0.002
HSA00310_LYSINE_ DEGRADATION	Genes involved in lysine degradation	Down	−1.70	0.006
MARCINIAK_CHOP_DIFF	Differentially-expressed genes in CHOP-negative mutant mouse embryo fibroblast cells after treatment with tunicamycin	Down	−1.60	0.006
JAIN_NEMO_DIFF	Genes from XHM-ED B cells that show abnormal regulation in response to CD40L plus IL-4	Down	−1.61	0.006
YAGI_AML_PROG_ASSOC	Prognosis-associated probe sets in acute myeloid leukemia	Down	−1.53	0.008
HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM	Genes involved in fructose and mannose metabolism	Down	−1.72	0.008
AMINOACYL_TRNA_BIOSYNTHESIS	Aminoacyl tRNA biosynthesis reference pathway	Down	−1.74	0.008
HSA00910_NITROGEN_METABOLISM	Genes in nitrogen metabolism	Down	−1.58	0.008
HDACI_COLON_CUR2HRS_UP	Genes upregulated by curcumin at 2 hrs in SW260 colon carcinoma cells	Up	1.61	0.010
TSADAC_HYPOMETH_HYPERAC_OVCA_UP	Genes with basally hypomethylated promoters upregulated by the combination of TsA and decitabine in ovarian carcinoma (CP70) cells, with hyperacetylated promoters upon activation	Down	−1.62	0.010