Table 3.

Histologic score differences between HFE genotypes

Histologic feature	WT/WT	ANY HFE	C282Y/WT and C282Y/H63D	H63D/WT and H63D/H63D
Steatosis (0-3)	1.8 ± 0.8	1.9 ± 0.8‡	1.9 ± 0.8	2.0 ± 0.8‡
Lobular inflammation (0-3)	1.6 ± 0.7	1.6 ± 0.7	1.5 ± 0.7	1.7 ± 0.7
Portal inflammation (0-2)	1.1 ± 0.6	1.1 ± 0.6	1.1 ± 0.6	1.1 ± 0.6
Fibrosis (0-4)	1.6 ± 1.3	1.6 ± 1.2	1.4 ± 1.2	1.6 ± 1.2
Hepatocellular ballooning (0-2)	1.1 ± 0.9	1.0 ± 0.9	0.9 ± 0.9†	1.1 ± 0.9#
NAS (0-8)	4.5 ± 1.6	4.6 ± 1.6	4.4 ± 1.6	4.7 ± 1.6†,#
Definitive NASH	298 (61)	168 (57)	50 (49)*	118 (61)

Values are mean ± SD except definitive NASH is N (%)

^‡P=0.001 vs WT/WT;

^†P< 0.05 vs WT/WT;

^#P< 0.05 vs C282Y/WT and C282Y/H63D from ordinal logistic regression after adjustment for sex, age, BMI and presence of diabetes.

^*P≤ 0.05 vs WT/WT or H63D/WT and H63D/H63D from logistic regression after adjustment for sex, age, BMI and presence of diabetes.