Table 3.
Sensitivity analyses of severe sepsis and subsequent depression with imputation of depression prevalence of new post-sepsis proxy-requiring respondentsa
17% depression prevalence among new post-sepsis proxy-requiring respondents45 | 45% depression prevalence among new post-sepsis proxy-requiring respondents46 | 95% depression prevalence among new post-sepsis proxy-requiring respondents47 | |
---|---|---|---|
Median RR for Effect of Sepsis | 0.90 | 1.03 | 1.16 |
95% Range for Point Estimates of Effect of Severe Sepsis (2.5th percentile – 97.5th percentile for point estimate of RRs for effect of sepsis) | 0.82–0.99 | 0.93–1.13 | 1.13–1.20 |
% of all simulations with statistically significant positive association between severe sepsis and depression | 0 | 0 | 0 |
Abbreviations (in alphabetical order): % = percent; RR = relative risk.
The results presented are from three sets of simulations of the fixed-effects regression analyses in which we imputed the presence of substantial depressive symptoms based on random assignment to patients who had converted from self-respondents pre-sepsis to requiring a proxy post-sepsis. These simulations were replicated 100 times.