Table 1.
Patient characteristics at diagnosis
| Patient ID | Sex, age (yr) | Duration of illness (months) | Serum Na+/K+ at diagnosis (mmol/liter)a | Peak serum cortisol (nmol/liter)b | Plasma ACTH (ng/liter)c | Adrenal cell Abd | 21-hydroxylase Ab (U/ml)e | HLA-DRB1 genotype | Personal or family autoimmunity |
|---|---|---|---|---|---|---|---|---|---|
| 1 | F 44 | 6 | 132/5.2 | 209 | >1250 | Neg | 0.68 | *0101/*1301 | Graves' disease |
| 2 | F 19 | 4 | 130/5.3 | 111 | >1250 | Pos | 345 | *0301/*0404 | Grandmother hypothyroid |
| 3 | F 38 | 12 | 132/4.4 | 80 | ND | Pos | 1669 | *0301/*0301 | Graves' disease; mother celiac |
| 4 | M 25 | 1.5 | 116/5.4 | 145 | 430 | Neg | 1.29 | *0101/*1501 | |
| 5 | F 17 | 6 | 118/4.9 | 235 | 629 | Pos | 19200 | *0301/*0801 | |
| 6 | M 47 | 4 | 130/5.0 | 70 | >1250 | Neg | 6.3 | *1301/*1501 |
F, Female; M, male; Neg, negative; Pos, positive; ND, not done.
a
Reference range for serum Na+ is 135–145 mmol/liter, K+ is 3.5–5.2 mmol/liter.
b
Reference range after tetracosactide is greater than 550 nmol. To convert from nanomoles per liter to micrograms per deciliter, divide by 27.6.
c
Reference range is 10–55 ng/liter.
d
Adrenal cell antibodies were measured by indirect immunofluorescence of patient sera on monkey adrenal slices (Prodiagnostics, Huntington, WV).
e
21-Hydroxylase antibodies were measured by immunoprecipitation.15 Reference range is less than 1.0 U/ml.