Table 1.
Between-group (controls vs. leptin-off patients) comparison of brain activations for the contrast food greater than nonfood
| Contrast | ROI area | Fasting |
Postprandial |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Coordinate |
Z-score | Coordinate |
Z-score | ||||||
| x | y | z | x | y | z | ||||
| Controls greater than patients (leptin-off) | Hypothalamus | ||||||||
| Orbitofrontal cortex | 36 | 44 | −12 | 3.36 | |||||
| Amygdala | |||||||||
| Hippocampus | |||||||||
| Insula | −42 | −6 | 0 | 3.35 | |||||
| Nucleus accumbens | |||||||||
| Caudate | |||||||||
| Putamen | |||||||||
| Globus pallidus | |||||||||
| Patients (leptin-off) greater than controls | Hypothalamus | ||||||||
| Orbitofrontal cortex | |||||||||
| Amygdala | 22 | −4 | −22 | 2.92 | |||||
| Hippocampus | |||||||||
| Insula | −46 | −12 | 12 | 3.10 | |||||
| Nucleus accumbens | −8 | 10 | −6 | 3.12 | |||||
| Caudate | 14 | 2 | 14 | 3.21 | |||||
| −6 | 10 | 14 | 3.46 | −8 | 8 | −6 | 3.50 | ||
| Putamen | −10 | 8 | −6 | 3.48 | |||||
| Globus pallidus | −10 | 8 | −4 | 3.41 | |||||
Coordinate indicates the highest activity voxel of the cluster by Montreal Neurological Institute systems. Negative x-axis coordinates indicate left hemisphere. Z-score represents level of significance.