Table 2.
Between-group (leptin-on vs. leptin-off patients) comparison of brain activations for the contrast food greater than nonfood
| Contrast | ROI area | Fasting |
Postprandial |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Coordinate |
Z-score | Coordinate |
Z-score | ||||||
| x | y | z | x | y | z | ||||
| Leptin-on greater than leptin-off | Hypothalamus | ||||||||
| Orbitofrontal cortex | 32 | 48 | −10 | 2.98 | |||||
| Amygdala | |||||||||
| Hippocampus | |||||||||
| Insula | |||||||||
| Nucleus accumbens | |||||||||
| Caudate | |||||||||
| Putamen | |||||||||
| Globus pallidus | |||||||||
| Leptin-off greater than leptin-on | Hypothalamus | ||||||||
| Orbitofrontal cortex | |||||||||
| Amygdala | −22 | 0 | −20 | 2.98 | |||||
| Hippocampus | −18 | −8 | −16 | 3.19 | |||||
| Insula | −42 | −16 | 10 | 4.26 | |||||
| Nucleus accumbens | |||||||||
| Caudate | 6 | 8 | −8 | 3.46 | |||||
| −4 | 6 | 0 | 3.02 | −4 | 6 | −8 | 3.34 | ||
| Putamen | −8 | 8 | −8 | 2.90 | |||||
| Globus pallidus | |||||||||
Coordinate indicates the highest activity voxel of the cluster by Montreal Neurological Institute systems. Negative x-axis coordinates indicate left hemisphere. Z-score represents level of significance.