Table 4.

SOs are effective for prevention and treatment of cancer in vivo

Triterpenoid	Cancer Model	Treatment or Prevention	Combination	Reference
CDDO-Im	Syngeneic L1210 leukemia and B16 melanoma models	Treatment	None	Place et al., 2003
CDDO	Xenograft of MDA-MB-435 ER-breast cancer cells	Treatment	None	Lapillonne et al., 2003
CDDO-Im	Xenograft of MDA-MB-468 ER-breast cancer cells	Treatment	TRAIL	Hyer et al., 2005
CDDO-Im	Liver carcinogenesis induced by aflatoxin in rats	Prevention	None	Yates et al., 2006
Liposomal CDDO	Xenograft of MCF7 ER + breast cancer cells stably overexpressing HER2	Treatment	None	Konopleva et al., 2006
CDDO-Im	Plasmacytomas in iMycEμ transgenic mice	Treatment	None	Han et al., 2006
CDDO-Me CDDO-Ea CDDO-Ma	Lung carcinogenesis induced by vinyl carbamate in A/J mice	Prevention	None	Liby et al., 2007a, 2008a
Liposomal CDDO-Me	4T1/BALB/c model of metastatic breast cancer	Treatment	None	Ling et al., 2007
Liposomal CDDO CDDO-Im	TRAF2DN/Bcl-2 transgenic mouse model of CLL and small B-cell lymphoma	Treatment	None	Kress et al., 2007
CDDO-Me	Xenograft of Kaposi's sarcoma cells	Treatment	None	Vannini et al., 2007
Liposomal CDDO-Me	APL cells from hMRP8-PML/RARα transgenic mice propagated into syngenic FVB-N mice	Treatment	ATRA	Tabe et al., 2007
di-CDDO (TP-225)	Skin carcinogenesis induced by UV radiation in “high-risk” hairless mice	Prevention	None	Dinkova-Kostova et al., 2008
CDDO-Me	Xenograft of Dul45 prostate cancer cells in nude rats	Treatment	None	Hyer et al., 2008
CDDO-Me	MMTV-neu model of ER- breast cancer	Both	LG100268	Liby et al., 2008b
CDDO-Me	Xenograft of PC-3 prostate cancer cells	Treatment	None	Deeb et al., 2009
CDDO-Me CDDO-EA	Lung carcinogenesis induced by vinyl carbamate in A/J mice	Both	LG100268 and NRX194204	Liby et al., 2009
CDDO-Me	Xenograft of MC38 colon cancer cells	Treatment	Tumor-associated antigen vaccine	Nagaraj et al., 2010
CDDO-Me	Xenograft of L3.6pL human pancreatic cancer cells	Treatment	None	Jutooru et al., 2010
CDDO-Me CDDO-EA	LSL-KrasG12D/+;LSL-Trp53R127H/+;Pdx-1-Cre mouse model of pancreatic cancer	Prevention	LG100268	Liby et al., 2010
CDDO-Im	Experimental metastasis model –B16F1 melanoma and HT-29 colon cancer cells injected into the mesenteric vein metastasize to the liver	Treatment	None	Townson et al., 2011
CDDO	TRAMP model	Prevention	None	Deeb et al., 2011
CDDO-Im nanoparticles	Orthotopic injection of primary MMTV-Neu or 4TO7 tumor cells into BALB/c or FVB/NJ mice	Treatment	HER-2 DNA vaccine	Liao et al., 2011
CDDO-Me	Brca1Co/Co;MMTV-Cre;p53+/− transgenic mouse model of BRCA1-mutated breast cancer	Prevention	None	Kim et al., 2012
CDDO-Me	PyMT model of ER- breast cancer	Prevention	None	Tran et al., 2012

MMTV, mouse mammary tumor virus; PyMT, polyoma middle T.