Figure 1. Clinical diagnostic process and aquaporin-4 (AQP4) antibody seropositivity in the present study.
We examined whether individual patients fulfilled the diagnostic criteria for neuromyelitis optica (NMO), other neuromyelitis optica spectrum disorders (ONMOSD), opticospinal multiple sclerosis (OSMS), classic multiple sclerosis (CMS), and clinically isolated syndrome (CIS) described in the Diagnostic criteria and process of clinical diagnosis section in this order. When a patient did not fulfill the diagnostic criteria for one disease, that disease was excluded, and the next diagnostic criteria were applied until certain criteria were met.