Table 4.
mRNA expression for a panel of cation transporters according to tumor MIBG avidity in 27 patients with neuroblastoma and centrally reviewed MIBG scans.a
| MIBG Avid (n = 19) |
MIBG Nonavid (n = 8) |
|
|---|---|---|
| Median OCT1 mRNA | 0.17% | 0.11% |
| (range) | (0.04–0.48%) | (0.03–0.90%) |
| Median OCT3 mRNA | 0.60% | 1.3% |
| (range) | (0.04–127%) | (0–6.47%) |
| Median MATE1 mRNA | 5.9% | 8.2% |
| (range) | (0.39–57%) | (0.43–102%) |
| Median VMAT1 mRNA | 89% | 13% |
| (range) | (0.68–348%) | (0.43–1590%) |
| Median VMAT2 mRNA | 175% | 27% |
| (range) | (2.7–2661%) | (0.98–1253%) |
aTransporter expression is expressed as a percent of PGK1 expression. OCT2 mRNA expression was observed in only two tumors.