Table 3.
Association between the allele frequency and genotype distribution of rs763780 polymorphism and patient's characteristics.
| Characteristics | Total number N = 311 | Genotype | P value | Allele | P value | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | C | T | |||||
| Age | |||||||||
| ≤45 year | 200 | 3 (1.5) | 53 (26.5) | 144 (72.0) | 0.831 | 59 (14.8) | 341 (85.2) | 0.850 | 0.96 (0.61–1.51) |
| >45 year | 111 | 1 (0.9) | 32 (28.8) | 78 (70.3) | 34 (15.3) | 188 (84.7) | |||
| Clinical stage | |||||||||
| I | 135 | 3 (2.2) | 43 (31.9) | 89 (65.9) | Ref | 49 (18.1) | 221 (81.9) | Ref | 0.66 (0.42–1.03) 0.347 (0.04–2.72) |
| II | 169 | 1 (0.6) | 41 (24.3) | 127 (75.1) | 0.137 | 43 (12.7) | 295 (87.3) | 0.064 | |
| III | 7 | 0 (0.0) | 1 (14.3) | 6 (85.7) | 0.547 | 1 (7.1) | 13 (92.9) | 0.292 | |
| Tumor differentiation | |||||||||
| Poor | 251 | 4 (1.6) | 72 (28.7) | 175 (69.7) | 0.312 | 80 (15.9) | 422 (84.1) | 0.159 | 1.56 (0.84–2.91) |
| Well-moderate | 60 | 0 (0.0) | 13 (21.7) | 47 (78.3) | 13 (10.8) | 107 (89.2) | |||
| Lymph node status | |||||||||
| Positive | 55 | 0 (0.0) | 16 (29.1) | 39 (70.9) | 0.626 | 16 (14.5) | 94 (85.5) | 0.895 | 0.96 (0.54–1.72) |
| Negative | 256 | 4 (1.6) | 69 (26.9) | 183 (71.5) | 77 (15.0) | 435 (85.0) | |||
| Parametrial invasion | |||||||||
| Positive | 95 | 2 (2.1) | 28 (29.5) | 65 (68.4) | 0.574 | 32 (16.8) | 158 (83.2) | 0.381 | 1.23 (0.77–1.96) |
| Negative | 216 | 2 (0.9) | 57 (26.4) | 157 (72.7) | 61 (14.1) | 371 (85.9) | |||
| Peritumor intravascular cancer emboli | |||||||||
| Positive | 121 | 2 (1.7) | 28 (23.1) | 91 (75.2) | 0.403 | 32 (13.2) | 210 (86.8) | 0.335 | 0.80 (0.50–1.27) |
| Negative | 190 | 2 (1.1) | 57 (30.0) | 131 (68.9) | 61 (16.1) | 319 (83.9) | |||
N corresponds to the number of individuals.
Adjusted by age, clinical stage, tumor differentiation, lymph node status, parametrial invasion and peritumor intravascular cancer emboli.
Poor: undifferentiated cell with a spindle shape and presence of nuclear fission; moderate: individual cell keratinization but no cellular bridge or keratin pearl formation; well: differentiated cells with keratin pearl.
Boldfaced values indicate a significant difference at the 5% level.