Table 1.
ANOVA showed a significant effect overall (Kruskal-Wallis, P = 0.0003). Dunn's post hoc test indicated significance for MPTP + HE3286 and MPTP +L-DOPA compared to MPTP + vehicle, P < 0.0001 and P < 0.05, respectively. There was no improvement with MPTP + HE3286 + L-DOPA compared to MPTP + L-DOPA (P > 0.05 by the Mann-Whitney test).
| Group | n |
Mean rotarod latency (sec) |
SD | 95% CI |
P versus MPTP + vehiclea |
|
|---|---|---|---|---|---|---|
| Expts | Mice | |||||
| Saline | 3 | 24 | 180 | 0 | 180-180 | |
| MPTP | 3 | 19 | 59.2 | 27.3 | 46–72 | |
| MPTP + vehicle | 3 | 22 | 58.2 | 27.5 | 46–70 | |
| MPTP + HE3286 | 3 | 21 | 90.9 | 18.4 | 83–99 | 0.0001 |
| MPTP + L-DOPA | 2 | 15 | 83.8 | 10.6 | 78–90 | 0.05 |
| MPTP + L-DOPA + HE3286 | 2 | 13 | 84.0 | 12.5 | 76–92 | |
aDunn's post hoc test.