Table 2.

Independent associations between baseline characteristics, ESRD, and pre-ESRD death

	ESRD				Pre-ESRD Mortality
	Cox Model		Competing Risks Model		Cox Model		Competing Risks Model
	Hazard Ratio (95% CI)	P Value	Subhazard Ratio (95% CI)	P Value	Hazard Ratio (95% CI)	P Value	Subhazard Ratio (95% CI)	P Value
Vascular disease	1.11 (0.91–1.36)	0.30	0.82 (0.60–1.13)	0.20	1.63 (1.20–2.20)	0.002	1.57 (1.15–2.14)	0.004
Agea	0.86 (0.81–0.91)	<0.001	0.80 (0.75–0.86)	<0.001	2.15 (1.81–2.56)	<0.001	2.13 (1.81–2.51)	<0.001
Female sex	0.92 (0.81–1.04)	0.20	0.94 (0.81–1.09)	0.40	0.79 (0.60–1.04)	0.10	0.87 (0.66–1.14)	0.30
African-American race	1.08 (0.90–1.31)	0.40	0.92 (0.70–1.20)	0.50	1.48 (1.01–2.16)	0.04	1.31 (0.89–1.93)	0.20
Current smoker	1.30 (1.09–1.55)	0.004	1.14 (0.93–1.41)	0.20	1.50 (1.01–2.23)	0.04	1.37 (0.92–2.03)	0.10
Systolic BPb	1.04 (1.00–1.08)	0.06	1.02 (0.98–1.08)	0.90	1.09 (1.02–1.17)	0.01	1.05 (0.98–1.13)	0.20
Diabetes status	1.47 (1.12–1.93)	0.01	0.97 (0.64–1.46)	0.90	2.13 (1.42–3.19)	<0.001	1.54 (1.03–2.32)	0.04
PKDc	3.04 (2.60–3.54)	<0.001	3.07 (2.49–3.77)	<0.001	0.52 (0.30–0.91)	0.02	0.30 (0.17–0.52)	<0.001
Glomerular diseasec	0.98 (0.84–1.14)	0.80	1.09 (0.91–1.31)	0.30	0.96 (0.69–1.34)	0.80	1.01 (0.72–1.41)	0.90
Log-proteinuria	2.00 (1.81–2.21)	<0.001	1.77 (1.59–1.98)	<0.001	1.19 (0.97–1.46)	0.10	0.71 (0.57–0.88)	0.002
Estimated GFRd	1.62 (1.56–1.70)	<0.001	1.55 (1.47–1.64)	<0.001	1.18 (1.08–1.29)	<0.001	0.92 (0.86–0.99)	0.03

95% CI, 95% confidence interval; PKD, polycystic kidney disease;

^aPer decade increase.

^bPer 10 mmHg increase.

^cReference: Other cause of kidney disease.

^dPer 10 ml/min per 1.73 m² lower.