Table 2.
Association of HBV infection and elevated ALT with reduced eGFR, albuminuria, and CKD
| HBV Infection | ALT+ | |
|---|---|---|
| Reduced eGFR | ||
| Model 1a | 1.04 (0.37–2.93) | 1.22 (0.64–2.35) |
| Model 2b | 1.15 (0.41–3.30) | 1.26 (0.65–2.44) |
| Albuminuria | ||
| Model 1a | 0.79 (0.53–1.19) | 1.15 (0.58–2.28) |
| CKD | ||
| Model 1a | 0.77 (0.52–1.19) | 1.12 (0.89–1.42) |
Data are odds ratios (95% confidence intervals). Multivariate logistic regressions were used to estimate odds ratios. All were P<0.05. ALT+, ALT levels ≥ the sex-specific 90th percentile values of noninfected persons in our study (28 U/L for women and 40 U/L for men); reduced eGFR, eGFR estimated with the Chinese eGFR Investigation Collaboration equation <60 ml/min per 1.73 m2. HBV, hepatitis B virus; ALT, alanine aminotransferase; eGFR, estimated GFR.
a
Model 1: Adjusted for age, sex, hypertension, diabetes, waist circumference, HDL cholesterol levels, total cholesterol levels, and nephrolithiasis;
b
Model 2: Adjusted as in for Model 1, plus albuminuria.