Fig. 8.

Dose response of MMP-2 inhibition by anacardic acid (AA). A, plot showing percentage inhibition of the MMP-2 catalytic core domain in the presence of different concentrations of anacardic acid isolated from CNSE (1–100 μM). ***, P < 0.001 (one-way analysis of variance with Dunnett's multiple-comparison post-test). B, dose-response curve and determination of IC₅₀ of anacardic acid-mediated inhibition of MMP-2 activity. Each bar represents the mean ± S.E. of triplicate determinations from three independent experiments.