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. 2012 Oct;82(4):679–686. doi: 10.1124/mol.112.080085

Fig. 5.

Fig. 5.

EPA and DHA metabolism catalyzed by purified CYP4V2 reconstituted with P450 reductase and cytochrome b5. a, EPA incubated with CYP4F3B Supersomes plus NADPH. b, EPA incubated with reconstituted CYP4V2 minus NADPH. c, EPA incubated with reconstituted CYP4V2 plus NADPH. d, DHA incubated with CYP4F3B Supersomes plus NADPH. e, DHA incubated with reconstituted CYP4V2 minus NADPH. f, DHA incubated with reconstituted CYP4V2 plus NADPH. Peaks were identified as 19-hydroxy-EPA, 20-hydroxy-EPA, 21-hydroxy-DHA, and 22-hydroxy-DHA. IS, internal standard.