Table 1.
Location and frequency of gene alleles contributing to warfarin response.
| Allele | Location | Frequency |
||
|---|---|---|---|---|
| European Caucasians | US Hispanics | African–Americans | ||
| CYP2C9*2 | Exon 3 | 0.10 | 0.07 | 0.02 |
| CYP2C9*3 | Exon 7 | 0.06 | 0.05 | 0.01 |
| CYP2C9*5 | Exon 7 | <0.01 | <0.01 | 0.01 |
| CYP2C9*6 | Exon 5 | <0.01 | <0.01 | 0.01 |
| CYP2C9*8 | Exon 3 | <0.01 | <0.01 | 0.06 |
| CYP2C9*11 | Exon 7 | <0.01 | <0.01 | 0.04 |
| CYP2C9 rs7089580 | Intronic | 0.24 | 0.11 | 0.23 |
| VKORC1 -1639A | 5-UTR | 0.40 | 0.46 | 0.11 |
| VKORC1 rs61162043 | 5-UTR | Unknown | Unknown | 0.47 |
| CALU rs339097 | Intronic | <0.01 | Unknown | 0.11–0.14 |
| CYP4F2 433M | Exon 2 | 0.23 | 0.22 | 0.09 |
| GGCX (CAA)16, 17 | Intronic | <0.01 | Unknown | 0.03 |