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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Mol Cancer Res. 2012 Aug 9;10(9):1203–1215. doi: 10.1158/1541-7786.MCR-12-0124

Figure 5. S-nitrosation is required for NO to activate β-catenin signaling.

Figure 5

(A) TCF-luciferase activity from MDA-MB-468 cells exposed to LiCl or 0.3 mM DETANO and inhibitors of nitrosation. (B) TCF-luciferase activity from MDA-MB-468 cells pretreated with NEM (black) or untreated (grey) followed by DETANO incubation. (C) TCF-luciferase activity from MDA-MB-468 cells exposed to 0.3 mM DETANO and kinase (Gefitinib, PP2, wortmannin and triciribine) and soluble guanylate cyclase (ODQ) inhibitors. Data represent fold-RLU relative to control (± sd). (D) Representative immunofluorescent images of β-catenin localization in MDA-MB-231 cells treated with 0.3 mM DETANO ± 100 nM PP2.