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. Author manuscript; available in PMC: 2013 Jan 10.
Published in final edited form as: J Control Release. 2011 Oct 28;158(2):319–328. doi: 10.1016/j.jconrel.2011.10.028

Fig. 6.

Fig. 6

Histologic evaluation of tissues from mice treated with saline, free DOX (single dose at 15 mg/kg), liposomal DOX (2 doses at 15 mg DOX/kg each), and NP3 (single dose at 60 mg DOX/kg). (A). Heart was sliced with 5-μm thickness for hematoxylin & eosin (H&E) and Schmorl’s staining. The yellow circles indicate areas of necrosis or inflammation of the heart. Schmorl’s staining confirmed some pigment (black dots in red circles) in the free DOX group and vacuoles in the liposomal DOX group. Bar, 20 μm. (B). Microphotographs of liver, spleen, kidney, and lung from mice in various treatment groups stained with H&E.