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. Author manuscript; available in PMC: 2012 Oct 3.
Published in final edited form as: Stroke. 2011 Jun 30;42(8):2356–2362. doi: 10.1161/STROKEAHA.111.619122

Figure 1.

Figure 1

Final 90 day outcome scores in the two NINDS-TPA trials. The NIHSS and Barthel Index both show a markedly skewed, U-shaped distribution, unfavorable for analytic power and clinical interpretation. The Barthel also shows strong ceiling effect. In contrast, the modified Rankin Scale distributes substantial groups of patients among all hierarchical ranks, permitting more robust analysis and interpretation.