Table 3.
Compiled Tensile and Compressive Mechanical Properties of the Cell-Seeded Scaffolds at Week 0 and 5
|
Week 0 |
Week 5 |
||
---|---|---|---|---|
Electrospun cartilage equivalent | Tensile modulus (MPa) | Tensile stress (MPa) | Tensile modulus (MPa) | Tensile stress (MPa) |
Aligned | 35±2 | 20±4 | 43±5 | 23±3 |
Random | 12.4±4.4 | 7.4±0.7 | 15±2.7 | 5±3.7 |
Trilaminar composite | 25±3 | 8.4±1 | 22±6.1 | 7±0.4 |
|
Week 0 |
Week 5 |
||
---|---|---|---|---|
Electrospun cartilage equivalent | Compressive modulus (kPa) | Compressive stress (kPa) | Compressive modulus (kPa) | Compressive stress (kPa) |
Aligned | 136.3±16.6 | 22.5±2.5 | 52.5±10.6 | 8.1±2 |
Random | 511.9±69 | 61.9±7 | 520.9±144 | 58±16.1 |
Trilaminar composite | 152.5±42.2 | 23.1±4.5 | 65.7±27.5 | 9.7±4.4 |
|
Excised tissue |
|
---|---|---|
Compressive modulus (kPa) | Compressive stress (kPa) | |
Native cartilage | 89.5±48.6 | 14.5±5.3 |
A 5-week growth period did not significantly affect the tensile properties, yet the compressive properties of the aligned and the trilaminar composite scaffold were significantly different with average stiffness reductions of 84 and 87 kPa, respectively. The random scaffold displayed no significant difference in stiffness. The stiffness values found for the native cartilage compare favorably with the 5-week growth period for the aligned and composite scaffolds.