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Schematic diagram showing the immunoprotective effect of nifetepimine on tumor-induced CD4+ T cell apoptosis. Nifetepimine prevents tumor-induced T cell death by down-modulating SERCA3 expression, which thereby blocks the apoptotic cascade on one hand and restores the survival pathway on the other, ultimately protecting the CD4+ T cells from tumor insult. PBL, peripheral blood lymphocytes.
