TABLE 1.

HS binding Weintraub sequences within Wnts

B means any basic amino acid residue. X means any amino acid residue. Weintraub sequences (in bold) are found in several Wnts, including Wnt3a that is known to induce canonical signaling in myogenic population. Wnts that have been shown to induce noncanonical signaling in myogenic cells, such as Wnt7a, lack Weintraub sequences. Note: not all Wnts listed in the table have been tested for their function during skeletal muscle regeneration or their activities in the canonical versus noncanonical signaling pathways in myogenic cells.

Protein	GI number	Reference number	Residues	Heparan sulfate binding concensus sequence (XBBBXBX or XBBXBX)
Wnt1	4885655	NP_005421.1	61–80	LQLLSRKQRR LIRQNPGILH
Wnt2	4507927	NP_003382.1	171–190	FVDAKERKGK DARALMNLHN
Wnt2b	13518017	NP_004176.2	181–200	KAFVDAKEKR LKDARALMNL
Wnt3	13540477	NP_110380.1	321–340	TRTEKRKEKC HCIFHWCCYV
Wnt3a	14916475	NP_149122.1	321–340	ERRREKCRCV FHWCCYVSCQ
Wnt4	17402922	NP_110388.2
Wnt5a	40806205	NP_003383.2
Wnt5b	14249180	NP_116031.1	251–270	SAAAMRVTRK GRLELVNSRF
Wnt6	16507239	NP_006513.1
Wnt7a	17505191	NP_004616.2
Wnt7b	17505193	NP_478679.1
Wnt8a	17505195	NP_490645.1
Wnt8b	110735437	NP_003384.2	271–290	ECLRRGRALG RWERRSCRRL
Wnt9a	15082261	NP_003386.1	61–80	RLKLERKQRR MCRRDPGVAE
Wnt9b	17017976	NP_003387.1	51–70	HLKQCDLLKL SRRQKQLCRR
Wnt10a	16936520	NP_079492.2	161–180	ASRRGDEEAF RRKLHRLQLD
Wnt10b	16936522	NP_003385.2	241–260	ENLKRKCKCH GTSGSCQFKT
Wnt11	17017974	NP_004617.2
Wnt16	17402916	NP_476509.1	261–280	DKTKRKMRRR EKDQRKIPIH