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. 2012 Jul 23;287(39):32825–32834. doi: 10.1074/jbc.M112.357467

FIGURE 6.

FIGURE 6.

The intermediate form is localized in the upper granular cells and is associated with KLK7 in normal human epidermis. A, localization of procaspase-14 (green fluorescence), mature caspase-14 (red fluorescence) and the intermediate form (brown color) in normal human epidermis. B, dual staining for KLK7 and the intermediate form. They are colocalized in the granular layer. The merged figure is also shown. C, association of KLK7 and the intermediate form. The PLA method indicated that KLK7 and procaspase-14, as well as KLK7 and the intermediate form, are associated together in the granular to cornified layer in normal human epidermis. Scale bars, 50 μm.