FIGURE 5.
HFD feeding increases 2-AG levels in rat hypothalami after only 3 days. A–C, measurements of key endocannabinoids in MBH tissue samples (n ≥ 7/group). D, Ra glycerol flux of 3-day HFD-fed male rats, which were intracerebroventricularly (ICV) infused with either rimonabant or vehicle for 6 h. Ra glycerol was measured at base line and after induction of a 3 milliunits·kg−1·min−1 hyperinsulinemic clamp. All error bars represent S.E. *, p < 0.05 versus RC-fed group. N.S., not statistically significant.