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. 2012 Aug 2;287(39):32546–32555. doi: 10.1074/jbc.M112.348755

FIGURE 6.

FIGURE 6.

Effects of inhibition of NADPH oxidase activity on cerebral ischemia/reperfusion injury and expression of TIPE2. A, Western blot analysis of NOX2 protein levels in brains from ischemic WT mice. B, summarized data showing the effect of the NADPH oxidase inhibitor apocynin (Apo) on superoxide production in ischemic brain. C, calculated infarct volume in ischemic WT mice with apocynin treatment after cerebral ischemia/reperfusion (I/R). D, neurological deficit scores in WT mice with apocynin treatment after cerebral ischemia/reperfusion. E, representative Western blots and quantified data showing the relative protein levels of TIPE2 in ischemic WT mouse cerebral cortex and hippocampus with apocynin treatment. *, p < 0.05; **, p < 0.01 for ischemic WT mice versus sham-operated WT mice (n = 8).