Table 1.
Hematological measurements in rats treated with 0.1 mL phosphate-buffered saline (PBS) (control), tissue plasminogen activator (tPA) in PBS (1 mg/mL), 10 mg/mL silica-coated magnetic nanoparticle (SiO2-MNP) in PBS, or 10 mg/mL SiO2-MNP-tPA in PBS (equivalent to 1 mg/mL tPA)
| Treatment | RBC (106/μL) | WBC (103/μL) | Platelet (103/μL) | HGB (g/dL) | HCT (%) |
|---|---|---|---|---|---|
| Control | 9.4 ± 0.5 | 5.2 ± 0.2 | 1054 ± 50 | 12.1 ± 0.6 | 48.9 ±1.4 |
| tPA | 8.9 ± 0.4 | 5.0 ± 0.3 | 850 ± 29* | 11.6 ± 0.5 | 47.2 ± 1.0 |
| SiO2-MNP | 9.1 ± 0.3 | 6.9 ± 0.1* | 804 ± 48* | 11.7 ± 0.7 | 49.8 ± 1.3 |
| SiO2-MNP-tPA | 9.2 ± 0.4 | 5.3 ± 0.3 | 1100 ± 76 | 11.8 ± 0.4 | 48.2 ± 1.2 |
Notes: Concentrations of red blood cells (RBC), white blood cells (WBC), platelets, hemoglobin (HGB), and hematocrit (HCT) were determined by automated hematology system (values presented as mean ± standard error).
*
P < 0.05 compared with control.