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Simulation 1 results. Probability of detection for ‘main’, ‘interacting’, and ‘null’ SNPs plotted against the number of total SNPs for select RF VIMs and logistic regression (LR). Top row shows results for the “main effects greater” Model 2; bottom row shows results for “interaction effects greater” Model 4. Results are plotted separately across MAF. Average PE estimates range between 0.430 and 0.476 ( Additional file 2 Table B3).
