Figure 2. Diagram with the proposed mechanism by which G2019S LRRK2 fibroblasts present an exacerbated MAPK1/3-dependent autophagy activity. Fibroblasts with the G2019S LRRK2 mutation show exacerbated kinase activity, which corresponds to an increase in the phosphorylated levels of MAPK1/3 activity at baseline with respect to control cells. Also, they present an exacerbated autophagic flux that is reverted using an inhibitor of the MAPK1/3 pathway, decreasing in the same manner the cell death observed in mutant cells.