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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Cancer Res. 2012 Aug 21;72(19):5060–5068. doi: 10.1158/0008-5472.CAN-12-1821

Figure 3. Pituitary tumour imaging and volumetric measurements.

Figure 3

A, Coronal MRI with gadodiamide enhancement, demonstrating a pituitary tumour (outlined in red dots). B, MRI section of the same tumour, immediately after delivery of an intra-tumoural injection; the black area in the brain, shown by the arrow, corresponds to the injected bolus. C, MRI section of the same tumour 24-hours after injection showing complete absorption of the bolus. D, MRI was used to assess tumour volumes, pre-treatment and four-weeks after intra-tumoural injection. Data are shown for each tumour; pre-treatment (open circles), and post-treatment (filled circles). E, Assessment of blood-filled spaces in Men1+/− pituitary tumours. A large area of a pituitary tumour is made up of spaces which are filled with blood (outlined in white, magnification x40). BrdU, 5-bromo-2′-deoxyuridine; DAPI, 4′,6-diamidino-2-phenylindole; PRL, prolactin; RBC, red blood cells. F, Quantification of pituitary sections from wild type mice (n=5) and pituitary tumours from Men1+/− mice (n=12) indicating the proportion of tissue area that is filled by blood-filled spaces (grey bars) compared to pituitary parenchyma cells (white bars).