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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: ChemMedChem. 2012 Mar 13;7(5):861–870. doi: 10.1002/cmdc.201200049

Scheme 2.

Scheme 2

Reagent and conditions: a) methylhydrozine, water, reflux, 5 h; or benzylhydrazine dihydrochloride, Et3N, water, reflux, overnight; b) water or methanol, reflux; c) 1. 1 N NaOH, rt, overnight; 2. HCl.