Table 3. Univariate and multivariate analysis of miR-148a expression, methylation and overall survival in stage IV MSS CRC patients.

			Univariate		Multivariate
		n	HR (95%CI)	p	HR (95%CI)	p
Age (years)	>60	35	1.0
	<60	36	0.91 (0.55–1.50)	0.71
Gender	Male	46	1.0
	Female	25	0.68 (0.40–1.16)	0.16
Tumor location	Colon	58	1.0
	Rectum	13	1.41 (0.76–2.60)	0.27
Performance status	0–1		1.0
	2		2.62 (1.26–5.43)	0.010a
miR-148a expression	High	36	1.0		1.0
	Low	35	1.79 (1.08–2.98)	0.026a	1.93 (1.15–3.23)	0.014a
miR-148a methylation	No	59	1.0		1.0
	Yes	12	2.76 (1.44–5.28)	0.002a	3.04 (1.56–5.93)	0.0011a

^ap<0.05.