Table 2. EC₅₀ values (ppc) for the replication-defective AdE1A12S, AdE1A1102, AdE1A1104 and AdE1A1108 viral mutants and wild type virus (Ad5).

	Ad5	Ad12S	Ad1102	Ad1104	Ad1108
PC3	102±10	3072±660	1710±450	5090±690	2100±250
DU145	8±2	240±25	148±35	255±50	80±20
22Rv1	1.8±0.5	5.2±1.1	6.1±2.0	13.3±3.5	5.5±3

Data are averages ± SD, n = 3, p<0.001 for all mutants vs Ad5 (t-test). The non-replicating dl312 and AdGFP control viruses had EC₅₀ values >1×10⁵ ppc.