Figure 8. Absence of laminin-α4 causes NMJ to age prematurely.

A. Axon terminals (left) and AChRs (middle panels) from diaphragm muscles of 6 month old lama4^−/− mice. The age-associated abnormalities observed in mutants at 6 months of age were similar to those seen in two-year-old wild type mice. B. Prevalence of axonal and terminal changes in lama4^−/− and wild type animals. At least 60 NMJs were analyzed for each genotype at each age. Scale Bar = 10 um.