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. 2012 Oct 3;7(10):e46911. doi: 10.1371/journal.pone.0046911

Figure 1. Schematic view of the temporal model and its simulation result.

Figure 1

(A) The model includes IKK activation, subsequent phosphorylation and proteosomal degradation of inhibitory protein IκBα, IκBβ, and IκBε, activation of NF-κB, and its translocation to nucleus where a gene for IκBα is expressed in the NF-κB-dependent manner. (B) The simulated oscillation of the temporal model (red line) and an experimental observation by Sung, M.L. et al., PLos ONE, 2009 [25] (dots) are shown. The concentration of nuclear NF-κB (NF-κBn) is normalized to the maximum value.