Table 2. Allele frequencies in PCOS cases and controls.
SNPs | Allele | Stage | Case | Ctrl | OR | P | ORmeta | Pmeta |
rs715790 | T/C | GWAS | 0.433 | 0.363 | 1.337 | 6.97E-05 | 1.230 | 1.89E-05 |
Replication | 0.407 | 0.374 | 1.151 | 0.021 | ||||
rs4449306 | C/A | GWAS | 0.440 | 0.382 | 1.270 | 9.60E-04 | 1.100 | 3.0E-04 |
Replication | 0.426 | 0.398 | 1.122 | 0.057 | ||||
rs6782041 | C/T | GWAS | 0.472 | 0.402 | 1.324 | 9.13E-05 | 1.090 | 2.0E-04 |
Replication | 0.455 | 0.432 | 1-098 | 0.114 |
Risk allele is shown in bold type.
GWAS: Genome-Wide Association Study.
OR: odds ratio.
The GWAS data and Replication data were combined.
Meta-analysis was performed to analyze the combined data.
ORmeta: odds ratio by meta-analysis.
Pmeta: P value by meta-analysis.