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. 2012 Oct 3;7(10):e46482. doi: 10.1371/journal.pone.0046482

Figure 5. KLF1 enhances the deposition of histone modifications associated with active genes.

Figure 5

ChIP performed on chromatin derived from K1-ERp cells treated with either vehicle control or 4-OHT. Antibodies were specific against (A) histone H3K4Me3, (B) acetylated histone H3, (C) CBP and (D) p300. Levels of H3K4Me3 and AcH3 were corrected to histone H3 occupancy. Target DNA enrichment relative to input was determined by Q-PCR using Alad1b promoter primers. *p value≤0.05. **p value ≤0.01 by Student’s t-test. Data shown represents the average of at least 3 independent experiments (mean ± SEM).