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Sequence comparison of the KK/HlJ mice that shows ectopic mineralization and C57BL/6J mice without mineralization. Sequencing of the Abcc6 gene at the 3′ end of exon 14 shows a C-to-T transition substitution (arrowheads), which in pre-mRNA is predicted to create a new splice donor site. Sequencing of the RT-PCR product (cDNA) shows a frame shift in the KK/HlJ mouse mRNA compared with the wild-type sequence in C57BL/6J. Wt, wild-type; Mu, mutant.
