Figure 5.

gddY mice had higher amounts of circulatory aberrantly glycosylated IgA than HIGA mice. A: Levels of serum IgA were increased in HIGA mice (left panel). However, after adjustment for serum IgA levels, high-molecular-weight IgA was more abundant in gddY mice (right panel). The loaded samples under reducing conditions were developed with anti-IgA antibody (lower panels). B: Serum IgA in gddY mice showed significantly lower binding to lectin SNA than that in HIGA and BALB/c mice and significantly lower binding to RCA-I than that in BALB/c mice. Eleven mice were evaluated in each group. The bars represent mean ± SD. *P < 0.01.