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A: p-Tau proteins stained using PHF1 antibody are detectable in synaptoneurosomes in brains affected by AD but not in control brains B: p-Tau localizes to both presynaptic (vGlut1) and postsynaptic (MAP2) terminals. Scale bar = 1 μm. C: Postsynapses have higher tau-positive percentages than do presynapses in AD temporal cortices (4 cases, 400 presynapses, 291 postsynapses). Error bars represent SEM. *P < 0.05, paired t-test.
