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. 2012 Oct;181(4):1426–1435. doi: 10.1016/j.ajpath.2012.06.033

Figure 8.

Figure 8

Correlations of various protein measurements in synaptoneurosomes in AD (12 cases, characterized in Figure 7). A and B: The levels of PHF1-reactive p-tau oligomers (oPHF1, 75 to 250 kDa) positively correlate with the levels of ubiquitin conjugates (Ub Conj, 75 to 250 kDa) and Rpt1 (subunit of 26S proteasome). C: There is a trend toward a significant correlation between oligomeric PHF1 and valosin-containing protein. Monomeric Aβ (mAβ) (D–F) and oligomeric Aβ (oAβ, dimers and trimers) (G–I) do not correlate with ubiquitin conjugates, proteasomes, and oligomeric PHF1. Linear regression is shown with 95% confidence intervals (dashed lines).