Table 2.
VMPFC and striatum region of interest analyses on task activations.
| BA | Side | Voxels | peak Z | p-corrected | x (mm) | y (mm) | z (mm) | |
|---|---|---|---|---|---|---|---|---|
| Money (Linear Contrast: 50¢ > 25¢ > 1¢ > 0¢): All Subjects | ||||||||
| Striatum: Caudate | L | 22 | +3.9 | 0.010 | −18 | −10 | 22 | |
| VMPFC: Pre/Subgenual ACC | 25,11 | L | 43 | −3.7 | 0.016 | −6 0 |
32 26 |
−2 −2 |
| Controls > CUD | ||||||||
| VMPFC: Subgenual ACC/Medial OFC | 25,10,11 | L | 18 | 3.9 | 0.005 | −9 | 44 | −11 |
| CUD > Controls | ||||||||
| None | ||||||||
| Money (Linear Contrast: 50¢ > 25¢ > 1¢ > 0¢): × Group Interaction | ||||||||
| Striatum: Putamen/Globus Pallidus | R | 68 | 3.4 | 0.044 | 27 | 2 | −2 | |
| Money (Linear Contrast: 50¢ > 25¢ > 1¢ > 0¢): CUD | ||||||||
| Striatum: Putamen/Globus Pallidus | R | 85 | +3.8 | 0.015 | 24 | 5 | −2 | |
| Striatum: Putamen/Globus Pallidus | L | 25 | +3.2 | 0.083 | −33 | 2 | 1 | |
| Money (Linear Contrast: 50¢ > 25¢ > 1¢ > 0¢): Controls | ||||||||
| None |
Statistical threshold: p<0.005 uncorrected and p<0.05 family-wise error (FWE) corrected at voxel-level, k >5 voxels;
Striatum was defined anatomically with PickAtlas to correspond to the caudate, putamen, and pallidum;
Ventromedial prefrontal cortex (VMPFC) was defined as an 18-mm radius sphere centered on x=−2, y=32, z=−18 (from Ersche et al., 2011);
ACC: anterior cingulate cortex; OFC: orbitofrontal cortex; R: right; L: left;
+/− Z values indicate direction of significant contrast;
Coordinates in bold font are depicted in the figures.