Table 4.
Pb Effects on Immune System Processa
| Gene Name | Ratiob | Direction | p-valuec | Gene ID |
|---|---|---|---|---|
| Histocompatibility 2, class II antigen A, alpha | 1.67 | Up | 0.000037 | H2-Aa |
| Chemokine (C-C motif) ligand 28 | 7.83 | Up | 0.000049 | Ccl28 |
| Myoglobin | 7.2 | Down | 0.000087 | Mb |
| Proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) | 1.69 | Down | 0.000675 | Psmb9 |
| Histocompatibility 2, class II antigen E alpha | 4.38 | Down | 0.001312 | H2-Ea |
| B-cell leukemia/lymphoma 2 | 2.42 | Up | 0.001448 | Bcl2 |
| T-cell immunoglobulin and mucin domain containing 2 | 2.75 | Up | 0.002678 | Timd2 |
| Retinoic acid receptor, alpha | 2.39 | Down | 0.003058 | Rara |
| Integrin alpha L | 4.14 | Down | 0.003366 | Itgal |
| Tnf receptor-associated factor 1 | 5.14 | Down | 0.003730 | Traf1 |
| Histocompatibility 28 | 4.1 | Down | 0.004093 | H28 |
| Hemoglobin, beta adult major chain | 3.27 | Up | 0.004094 | Hbb-b1 |
| CEA-related cell adhesion molecule 1 | 2.35 | Up | 0.005901 | Ceacam1 |
| Myeloid leukemia factor 1 | 2.49 | Down | 0.006808 | Mlf1 |
| Killer cell lectin-like receptor, subfamily A, member 7 | 4.39 | Down | 0.007948 | Klra7 |
| Recombination activating gene 1 | 10.64 | Down | 0.011999 | Rag1 |
| Interleukin 6 receptor, alpha | 1.61 | Down | 0.013099 | Il6ra |
| Immunoglobulin superfamily, member 6 | 3.19 | Down | 0.015717 | Igsf6 |
| Interleukin 6 receptor, alpha | 1.58 | Down | 0.017767 | Il6ra |
| Immunoglobulin kappa chain variable 1–135 | 2.78 | Down | 0.017858 | Igkv1–135 |
| Complement component 2 (within H-2S) | 4.74 | Up | 0.020775 | C2 |
| Immunoglobulin kappa chain variable 1 (V1) | 5.19 | Up | 0.021944 | Igk-V1 |
| C-type lectin domain family 2, member g | 5.91 | Down | 0.022073 | Clec2g |
| CD79A antigen (immunoglobulin-associated alpha) | 2.59 | Down | 0.022193 | Cd79a |
| Interferon-induced protein with tetratricopeptide repeats 1 | 1.88 | Down | 0.024193 | Ifit1 |
| Macrophage activation 2 like | 2.06 | Up | 0.026871 | Mpa2l |
| Granzyme D | 12.94 | Up | 0.028200 | Gzmd |
| Pre-B-cell leukemia transcription factor 4 | 4.67 | Down | 0.030148 | Pbx4 |
| Interleukin 7 receptor | 2.06 | Up | 0.032943 | Il7r |
| Chemokine (C-C motif) receptor 2 | 6.04 | Up | 0.033524 | Ccr2 |
| mast cell protease 6 | 2.35 | Down | 0.033642 | - |
| Activin A receptor, type II-like 1 | 1.65 | Up | 0.035090 | Acvrl1 |
| Complement component 9 | 3.21 | Down | 0.038159 | C9 |
| Toll-like receptor 5 | 5.91 | Down | 0.039706 | Tlr5 |
| Mannan-binding lectin serine peptidase 1 | 2.37 | Down | 0.039755 | Masp1 |
| Killer cell lectin-like receptor subfamily B member 1F | 1.96 | Up | 0.039827 | Klrb1f |
| Complement factor H-related 1 | 14.51 | Down | 0.039899 | Cfhr1 |
| Chemokine (C-C motif) receptor 8 | 1.7 | Up | 0.040092 | Ccr8 |
| Interleukin 4 receptor, alpha | 3.52 | Up | 0.040116 | Il4ra |
| CEA-related cell adhesion molecule 11 | 6.79 | Up | 0.040410 | Ceacam11 |
| Chemokine (C-C motif) receptor 2 | 4.97 | Up | 0.042378 | Ccr2 |
| Histocompatibility 2, K1, K region | 5.25 | Up | 0.044974 | H2-K1 |
| Signaling lymphocytic activation molecule family member 1 | 3.53 | Down | 0.045683 | Slamf1 |
| Notch gene homolog 4 (Drosophila) | 1.67 | Up | 0.045962 | Notch4 |
| Killer cell lectin-like receptor, subfamily A, member 16 | 8.46 | Down | 0.046071 | Klra16 |
| Interferon (alpha and beta) receptor 2 | 1.77 | Down | 0.047266 | Ifnar2 |
| Inhibin beta E | 4.53 | Up | 0.049989 | Inhbe |
a
Analysis performed by GeneSifter Software on Affymetrix 430A microarray data on whole brain RNA from 3 control and 3 Pb treated litters.
b
Expression fold-change of Pb-treated versus control.
c
Significant by Student's t-test at p<0.05.