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. Author manuscript; available in PMC: 2013 Oct 3.
Published in final edited form as: J Am Chem Soc. 2012 Sep 24;134(39):16171–16174. doi: 10.1021/ja3078126

Scheme 1.

Scheme 1

Proposed mechanism for the oxidation of (S)- and (R)-HPP by HppE. (A) Conversion of (S)-HPP (2) to fosfomycin (1). (B) Conversion of (R)-HPP (3) to 2-oxopropylphosphonic acid (4).