A, Representative immunohistochemical staining of Tgfbr1, p-S6, and survivin in human head and neck cancer tissue (right panel) compared with oral mucosa (left panel). B, Survivin levels correlate with pathological classification and lymph metastasis of head and neck cancer. C, Negative correlation between the expression of Tgfbr1 and survivin (P <0.05, n=57) in human head and neck cancer tissues. Histoscore based on quantification using Aperio quantification software and statistics with Graph Pad Prism5 (Mean ± SEM, ***, P<0.001, Two tailed Pearson correlation statistics).